Biswas, Rayhan G.; Ray, Sumit K.; Unhale, Rajshekhar A.; Singh, Vinod K. published an article in 2021. The article was titled 《Organocatalytic Asymmetric Cascade Michael-acyl Transfer Reaction between 2-Fluoro-1,3-diketones and Unsaturated Thiazolones: Access to Fluorinated 4-Acyloxy Thiazoles》, and you may find the article in Organic Letters.Name: Methyl 4-fluorobenzoate The information in the text is summarized as follows:
Quinine derived bifunctional urea catalyzed cascade Michael-acyl transfer reaction of 5-alkenyl thiazolones I (R = H, 2-Br, 3-Cl, 4-CF3, etc.; Ar = 4-fluorophenyl, naphthalen-2-yl, thien-2-yl, etc.) and monofluorinated β-diketones R1C(O)CH(F)C(O)R2 (R1 = Me, Ph, 4-chlorophenyl, etc.; R2 = Ph, 2-methylphenyl, 4-chlorophenyl, etc.) has been developed. The fluorine containing 4-acyloxy thiazoles (1R,2S)-II were synthesized in high yields and good diastereo- and excellent enantioselectivities. Synthetic transformations, including synthesis of 4-hydroxy thiazoles (1R,2S)-II, have been demonstrated. In the experiment, the researchers used many compounds, for example, Methyl 4-fluorobenzoate(cas: 403-33-8Name: Methyl 4-fluorobenzoate)
Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Name: Methyl 4-fluorobenzoate
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