Name: tert-Butyl carbamateIn 2022 ,《Fluorine-induced diastereodivergence discovered in an equally rare enantioselective syn-aza-Henry reaction》 was published in Chemical Science. The article was written by Bing, Jade A.; Schley, Nathan D.; Johnston, Jeffrey N.. The article contains the following contents:
In attention to the aza-Henry reaction, particularly over the past two decades, a wide range of effective catalysts has been resulted for the enantio- and diastereoselective versions, driven by the versatility of the β-amino nitroalkane products RCH(R1)NO2 (R = H, F; R1 = Ph, 2-phenylethyl) as precursors to secondary amines anti/syn- RC(NO2)R1CH(R2)NH(C(O)2C(CH3)3) (R2 = 2,2-dimethylpropyl, CH2=CH(CH2)2, Ph, 4-chlorophenyl) and vic-diamines. Despite this broad effort, syn-diastereoselective variants are exceedingly rare. A subset of α-fluoro nitroalkane additions that are characterized by an unusual crossover in diastereoselection, often delivering the products with high selectivities is discovered. A rigorous comparative anal. of non-fluorinated and α-fluoro nitroalkanes in their additions to azomethines have been reported here. Both homogeneous and heterogeneous catalysis were applied to probe the possibility that this phenomenon might be more widely operative in the enantioselective additions of fluorine-substituted carbon nucleophiles. A complete correlation within four categories is described that a clear trend is uncovered, while revealing a dramatic and distinct reversal of diastereoselection that would normally go undetected. In the experiment, the researchers used tert-Butyl carbamate(cas: 4248-19-5Name: tert-Butyl carbamate)
tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Name: tert-Butyl carbamate
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