Application In Synthesis of Ethyl 2-methyl-3-oxobutanoateIn 2021 ,《Palladium-catalyzed Tsuji-Trost-type reaction of benzofuran-2-ylmethyl acetates with nucleophiles》 was published in RSC Advances. The article was written by Arcadi, Antonio; Fabrizi, Giancarlo; Fochetti, Andrea; Ghirga, Francesca; Goggiamani, Antonella; Iazzetti, Antonia; Marrone, Federico; Mazzoccanti, Giulia; Serraiocco, Andrea. The article contains the following contents:
The palladium-catalyzed benzylic-like nucleophilic substitution of benzofuran-2-ylmethyl acetates with N, S, O and C soft nucleophiles was investigated. The success of the reaction was dramatically influenced by the choice of catalytic system: with nitrogen based nucleophiles the reaction worked well with Pd2(dba)3/dppf, while with sulfur, oxygen and carbo-nucleophiles [Pd(η3-C3H5)Cl]2/XPhos was more efficient. The regiochem. outcome showeds that the nucleophilic substitution occurs only on the benzylic position of the η3-(benzofuryl)methyl complex. The high to excellent yields and the simplicity of the exptl. procedure made this protocol a versatile synthetic tool for the preparation of 2-substituted benzofurans I [R = CH2N(Me)(Ph), CH2SO2Ph, 4-MeOC6H4OCH2, etc.; R1 = H, 7-OMe, 5-NO2]. The experimental process involved the reaction of Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Application In Synthesis of Ethyl 2-methyl-3-oxobutanoate)
Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Application In Synthesis of Ethyl 2-methyl-3-oxobutanoate
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