On March 22, 2021, Wang, Yongtao; Lu, Rui; Yao, Jia; Li, Haoran published an article.SDS of cas: 10472-24-9 The title of the article was 1,5,7-Triazabicyclo[4.4.0]dec-5-ene Enhances Activity of Peroxide Intermediates in Phosphine-Free α-Hydroxylation of Ketones. And the article contained the following:
The critical role of double hydrogen bonds was addressed for the aerobic α-hydroxylation of ketones catalyzed by 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD), in the absence of either a metal catalyst or phosphine reductant. Exptl. and theor. investigations were performed to study the mechanism. In addition to initiating the reaction by proton abstraction, a more important role of TBD was revealed, i.e., to enhance the oxidizing ability of peroxide intermediates, allowing DMSO to be used rather than commonly used phosphine reductants. Further characterizations with nuclear Overhauser effect spectroscopy (NOESY) confirmed the presence of double hydrogen bonds between TBD and the ketone, and kinetic studies suggested the attack of dioxygen on the TBD-enol adduct to be the rate-determining step. This work should encourage the application of TBD as a catalyst for oxidations The experimental process involved the reaction of Methyl 2-cyclopentanonecarboxylate(cas: 10472-24-9).SDS of cas: 10472-24-9
The Article related to aerobic hydroxylation ketone triazabicyclodecene catalyst green chem mol modeling, aerobic hydroxylation, double hydrogen bonds, guanidine, peroxide, reaction mechanism, Alicyclic Compounds: Cyclohexanes and other aspects.SDS of cas: 10472-24-9
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