Wang, Yan’s team published research in Science China: Chemistry in 2022 | CAS: 609-14-3

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Application In Synthesis of Ethyl 2-methyl-3-oxobutanoate

In 2022,Wang, Yan; Yihuo, Aying; Wang, Lifeng; Dong, Shunxi; Feng, Xiaoming published an article in Science China: Chemistry. The title of the article was 《Catalytic asymmetric synthesis of chiral azo compounds via interrupted Japp-Klingemann reaction with aryldiazonium saltsã€?Application In Synthesis of Ethyl 2-methyl-3-oxobutanoate The author mentioned the following in the article:

Asym. synthesis of enantioenriched azo compounds bearing tetrasubstituted stereocenter RC(N=NAr)(R1)C(O)R2 (R = 1,3-benzothiazol-2-yl, 1,3-benzoxazol-2-yl, quinazolin-4-yl, etc; R1 = F, Me, cyclopropylmethyl, etc.; R2 = dimethylaminyl, morpholin-4-yl, OMe, etc.; Ar = Ph, 2H-1,3-benzodioxol-5-yl, naphthalen-2-yl, etc.) was achieved through chiral N,N’-dioxide/metal Lewis acid promoted interrupted Japp-Klingemann reaction of aryldiazonium tetrafluoroborate salts Ar(N2)+BF4- with nucleophiles RCH(R1)C(O)R2 under mild conditions. This protocol features wide substrate scope and good functional group compatibility. Azaarene-containing chiral azo compounds were stable enough in Japp-Klingemann reaction condition. The key to success of the reaction was the employment of metal salt/N,N’-dioxide ligand and the dual-task roles of the base. Moreover, the X-ray crystal structure of Ni(II)/N,N’-dioxide/substrate complex confirmed that the substrate was activated by bidentate coordination, which shed light on the origin of chiral control of the reaction. The results came from multiple reactions, including the reaction of Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Application In Synthesis of Ethyl 2-methyl-3-oxobutanoate)

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Application In Synthesis of Ethyl 2-methyl-3-oxobutanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics