Tsuji, Hiroaki; Takahashi, Yoshiyuki; Kawatsura, Motoi published their research in Tetrahedron Letters in 2021. The article was titled ãNickel-catalyzed hydroalkylation of 1,3-dienes with malonates using a homoallyl carbonate as the 1,3-diene and hydride sourceã?Product Details of 609-08-5 The article contains the following contents:
The nickel-catalyzed hydroalkylation of 1,3-dienes with malonates using homoallyl carbonates RCH(OCOOCH3)CH2CH=CH2 (R = 4-chlorophenyl, piperonyl, cyclohexyl, etc.) as the 1,3-diene and hydride source was reported. A broad range of homoally carbonates and malonate derivatives R1CH(COOR2)2 (R1 = H, Ph, Me, i-Bu, etc.; R2 = Et, i-Pr, Me, Bn, t-Bu) was well tolerated under a Ni/DPEphos catalyst system, providing the corresponding 1,2-hydroalkylation products RCH=CH2CH(CH3)CH((COOCH3)2)CH3 in 40-94% yields with excellent regioselectivity. Also, suggested the possible reaction mechanism for the nickel-catalyzed hydroalkylation of in situ generated 1,3-dienes with malonates is suggested. In addition to this study using Diethyl 2-methylmalonate, there are many other studies that have used Diethyl 2-methylmalonate(cas: 609-08-5Product Details of 609-08-5) was used in this study.
Diethyl 2-methylmalonate(cas: 609-08-5) belongs to aliphatic hydrocarbons. Aliphatic hydrocarbons belong to the most abundant fraction in crude oil. Aliphatics molecules are linear or branched open-chain structures such as n-alkanes, isoalkanes, cycloalkanes (naphthenes), terpenes and steranes.Product Details of 609-08-5
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