On December 31, 2019, Tokhadze, N.; Chennell, P.; Bernard, L.; Lambert, C.; Pereira, B.; Mailhot-Jensen, B.; Sautou, V. published an article.Reference of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate The title of the article was Impact of alternative materials to plasticized PVC infusion tubings on drug sorption and plasticizer release. And the article contained the following:
The aim of this study was to assess interactions between drugs and five alternative materials to a reference plasticized PVC i.v. (IV) infusion tubing: three were PVC coextruded with polyethylene (PE), polyurethane (PU) or a thermoplastic elastomer (Styrene-EthyleneButadiene-Styrene (SEBS)) and two were SEBS or thermoplastic olefin (TPO) monolayer tubings. Diazepam and insulin were chosen as resp. reference of absorption and adsorption while paracetamol acted as a neg. control. The concentration of each drug was quantified with liquid chromatog. to evaluate a potential loss after a static contact condition and simulated infusion at 1 mL/h and 10 mL/h dynamic condition by an elec. syringe pump. Plasticizer release was quantified by GC-MS. For all tubings except PVC/PU, no loss of paracetamol was observed in any condition. PVC tubings induced the least loss of insulin amongst all the studied materials. Coextruded PVC/SEBS and PVC/PE presented the lowest zeta potential of all studied materials with resp. values of -39 mV and -36 mV and were related to the highest sorption of insulin while PVC/PU with the highest zeta potential (about -9 mV) presented the highest absorption of diazepam. Coextruded layered materials appeared to have a lower plasticizer release than PVC alone. As a conclusion, PVC/PE and thermoplastic elastomers alone or coextruded with PVC could be interesting alternatives to PVC tubings with regards to sorption phenomena and plasticizer release. The experimental process involved the reaction of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate(cas: 3319-31-1).Reference of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate
The Article related to pvc infusion tubing drug sorption plasticizer release, Pharmaceuticals: Pharmaceutics and other aspects.Reference of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate
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