On June 30, 2020, Seto, Yoshiki; Ohtake, Hiroto; Sato, Hideyuki; Onoue, Satomi published an article.Application of 85-91-6 The title of the article was Phototoxic risk assessment of dermally-applied chemicals with structural variety based on photoreactivity and skin deposition. And the article contained the following:
This study aimed to verify the feasibility of the screening system for phototoxic risk assessment on dermally-applied chems. with wide structural diversity, as a first attempt. Photochem. properties of test chems., 2-acetonaphthalene, 4′-methylbenzylidene camphor, 6-methylcoumarin, Me N-methylanthranilate, and sulisobenzone, were evaluated in terms of UV absorption and reactive oxygen species (ROS) generation, and PK profiles of the test chems. in rat skin were characterized after dermal co-application. All test chems. showed strong UVA/B absorption with molar extinction coefficients of over 3000 M-1·cm-1, and irradiated 2-acetonaphthalene, 6-methylcoumarin, and Me N-methylanthranilate exhibited significant ROS generation. Dermally-applied 2-acetonaphthalene and 4′-methylbenzylidene camphor indicated high and long-lasting skin deposition compared with the other test chems. Based on the photochem. and PK data, 2-acetonaphthalene was predicted to have potent phototoxic risk. The predicted phototoxic risk of the test chems. by integration of obtained data was mostly consistent with their in vivo phototoxicity observed in rat skin. The screening strategy employing photochem. and PK data would have high prediction capacity and wide applicability for photosafety evaluation of chems. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).Application of 85-91-6
The Article related to uv a acetonaphthalene sulisobenzone phototoxicity skin, cassette-dosing pharmacokinetics, photosafety, phototoxicity, reactive oxygen species, structural diversity, Radiation Biochemistry: Other and other aspects.Application of 85-91-6
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