In 2016,Sellars, Jonathan D.; Skipsey, Mark; Sadr-ul-Shaheed; Gravell, Sebastian; Abumansour, Hamza; Kashtl, Ghasaq; Irfan, Jawaria; Khot, Mohamed; Pors, Klaus; Patterson, Laurence H.; Sutton, Chris W. published ãRational Development of Novel Activity Probes for the Analysis of Human Cytochromes P450ã?ChemMedChem published the findings.Synthetic Route of C10H22N2O2 The information in the text is summarized as follows:
The identification and quantification of functional cytochromes P 450 (CYPs) in biol. samples is proving important for robust analyses of drug efficacy and metabolic disposition. A novel CYP activity-based probe was rationally designed and synthesized, demonstrating selective binding of CYP isoforms. The dependence of probe binding upon the presence of NADPH permits the selective detection of functionally active CYP. This allows the detection and anal. of these enzymes using biochem. and proteomic methodologies and approaches. The experimental part of the paper was very detailed, including the reaction process of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3Synthetic Route of C10H22N2O2)
Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).Synthetic Route of C10H22N2O2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics