On November 20, 2015, Salamone, Stephane; Guerreiro, Catherine; Cambon, Emmanuelle; Hargreaves, Jason M.; Tarrat, Nathalie; Remaud-Simeon, Magali; Andre, Isabelle; Mulard, Laurence A. published an article.Synthetic Route of 707-07-3 The title of the article was Investigation on the Synthesis of Shigella flexneri Specific Oligosaccharides Using Disaccharides as Potential Transglucosylase Acceptor Substrates. And the article contained the following:
Chemo-enzymic strategies hold great potential for the development of stereo- and regioselective syntheses of structurally defined bioactive oligosaccharides. Herein, we illustrate the potential of the appropriate combination of a planned chemo-enzymic pathway and an engineered biocatalyst for the multistep synthesis of an important decasaccharide for vaccine development. We report the stepwise investigation, which led to an efficient chem. conversion of allyl α-D-glucopyranosyl-(1â?)-α-L-rhamnopyranosyl-(1â?)-2-deoxy-2-trichloroacetamido-β-D-glucopyranoside, the product of site-specific enzymic α-D-glucosylation of a lightly protected non-natural disaccharide acceptor, into a pentasaccharide building block suitable for chain elongation at both ends. Successful differentiation between hydroxyl groups features the selective acylation of primary alcs. and acetalation of a cis-vicinal diol, followed by a controlled per-O-benzylation step. Moreover, we describe the successful use of the pentasaccharide intermediate in the [5 + 5] synthesis of an aminoethyl aglycon-equipped decasaccharide, corresponding to a dimer of the basic repeating unit from the O-specific polysaccharide of Shigella flexneri 2a, a major cause of bacillary dysentery. Four analogs of the disaccharide acceptor were synthesized and evaluated to reach a larger repertoire of O-glucosylation patterns encountered among S. flexneri type-specific polysaccharides. New insights on the potential and limitations of planned chemo-enzymic pathways in oligosaccharide synthesis are provided. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Synthetic Route of 707-07-3
The Article related to oligosaccharide pp polysaccharide shigella flexneri bacillary dysentery glucosylation transglucosylase, Carbohydrates: Oligosaccharides and other aspects.Synthetic Route of 707-07-3
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