On April 13, 2006, Robillard, Marc S.; Gruell, Holger published a patent.Application In Synthesis of tert-Butyl 2-(2-(2-(tosyloxy)ethoxy)ethoxy)acetate The title of the patent was Targeted imaging and/or therapy using the Staudinger ligation. And the patent contained the following:
The use of a selective chem. and bioorthogonal reaction providing a covalent ligation such as the Staudinger ligation (reaction between an azide and a phosphine), in targeted mol. imaging and therapy is presented, more specifically with interesting applications for pre-targeted imaging or therapy. Current pre-targeted imaging is hampered by the fact that it relies solely on natural/biol. targeting constructs (i.e. biotin/streptavidin). Size considerations and limitations associated with their endogenous nature severely limit the number of applications. The present invention describes how the use of an abiotic, bio-orthogonal reaction which forms a stable adduct under physiol. conditions, by way of a small or undetectable bond, can overcome these limitations. As an example of pre-targeted imaging, injection of a targeting probe comprising a somatostatin receptor-binding peptide linked to an azide is followed by a secondary radiolabeled probe linked to a Staudinger phosphine group. Following in vivo Staudinger ligation, the radiolabel enables detection of the presence of somatostatin receptor-pos. tissue such as neuroendocrine tumor. The experimental process involved the reaction of tert-Butyl 2-(2-(2-(tosyloxy)ethoxy)ethoxy)acetate(cas: 882518-89-0).Application In Synthesis of tert-Butyl 2-(2-(2-(tosyloxy)ethoxy)ethoxy)acetate
The Article related to staudinger ligation targeted imaging therapy, azide phosphine reaction targeted contrast agent delivery, Pharmaceuticals: Pharmaceutics and other aspects.Application In Synthesis of tert-Butyl 2-(2-(2-(tosyloxy)ethoxy)ethoxy)acetate
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