ãDirect remote δ-C(sp2)-H olefination of β-aryl-substituted aliphatic aldehydes via palladium/enamine co-catalysisã?was published in Organic Chemistry Frontiers in 2020. These research results belong to Richa; Kumar, Rajesh; Zhang, Xiaofeng; Su, Weiping. Application of 2495-35-4 The article mentions the following:
Palladium/secondary amine co-catalysis strategy that enables olefination of the remote C(sp2)-H bonds at positions δ or ε to the aldehyde group of β/γ-aryl-substituted aliphatic aldehydes was reported. The success of this strategy was attributed to the in situ generated transient enamine as a directing group that, after undergoing α-palladation, makes remote δ or ε aromatic C-H bonds accessible for activation. Diverse β/γ-aryl-substituted aliphatic aldehydes, including the derivatives of natural products and drug mols., was efficiently olefinated. The merit of this strategy was demonstrated by the scale-up synthesis and post-synthetic modification of the product to various useful functional groups. Mechanistic investigations supported our hypothesis of involvement of enamine α-palladation in the C-H bond activation step. In the experiment, the researchers used many compounds, for example, Benzyl acrylate(cas: 2495-35-4Application of 2495-35-4)
Benzyl acrylate(cas: 2495-35-4) has been used in preparation of high refractive index polyacrylates. Benzyl acrylate is used in the preparation of heptanoic acid benzyl ester. It is used to prepare polybenzylacrylate using azobisisobutyronitrile as initiator.Application of 2495-35-4
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