On November 7, 1997, Plummer, Mark S.; Holland, Debra R.; Shahripour, Aurash; Lunney, Elizabeth A.; Fergus, James H.; Marks, James S.; McConnell, Patrick; Mueller, W. Thomas; Sawyer, Tomi K. published an article.Formula: C10H19NO4 The title of the article was Design, Synthesis, and Cocrystal Structure of a Nonpeptide Src SH2 Domain Ligand. And the article contained the following:
The specific association of an SH2 domain with a phosphotyrosine (pTyr)-containing sequence of another protein precipitates a cascade of intracellular mol. interactions (signals) which effect a wide range of intracellular processes. The nonreceptor tyrosine kinase Src, which has been associated with breast cancer and osteoporosis, contains an SH2 domain. Inhibition of Src SH2-phosphoprotein interactions by small mols. will aid biol. proof-of-concept studies which may lead to the development of novel therapeutic agents. Structure-based design efforts have focused on reducing the size and charge of Src SH2 ligands while increasing their ability to penetrate cells and reach the intracellular Src SH2 domain target. In this report we describe the synthesis, binding affinity, and Src SH2 cocrystal structure of a small, novel, nonpeptide, urea-containing SH2 domain ligand. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Formula: C10H19NO4
The Article related to src sh2 domain nonpeptide ligand preparation, Pharmacology: Structure-Activity and other aspects.Formula: C10H19NO4
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