On June 30, 2017, Pan, Tingting; Xia, Chunguang; Jiang, Huijuan; Zhang, Zhongtang; Zhu, Xueyan; Yang, Yulei published an article.Category: esters-buliding-blocks The title of the article was Chemical synthesis of the ODM-201’s diastereomers through an efficient intramolecular 1,3-dipolar cycloaddition. And the article contained the following:
An efficient synthesis of ODM-201’s diastereomers has been developed from (R)-Me 3-hydroxybutanoate or (S)-Me 3-hydroxybutanoate, resp., with high overall yield and excellent diastereomeric purity. The key step in this synthesis is the preparation of the key intermediate (R)-5-(1-((tert-butyldimethylsilyl)oxy)ethyl)-1H-pyrazole-3-carboxylic acid or (S)-5-(1-((tert-butyldimethylsilyl)oxy)ethyl)-1H-pyrazole-3-carboxylic acid through intramol. 1,3-dipolar cycloaddition of the vinyl diazo carbonyl compounds The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).Category: esters-buliding-blocks
The Article related to odm201 diastereomer chem synthesis intramol dipolar cycloaddition, odm-201, diastereomer, intramolecular 1,3-dipolar cycloaddition, synthesis, Pharmaceuticals: General and other aspects.Category: esters-buliding-blocks
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics