HPLC of Formula: 51644-96-3In 2022 ,ãDesign, synthesis, and biological evaluation of quinazoline derivatives with covalent reversible warheads as potential FGFR4 inhibitorsã?appeared in Bioorganic Chemistry. The author of the article were Nie, Wenwen; Lu, Yang; Pan, Chenghao; Gao, Jian; Luo, Mengxin; Du, Jiaming; Wang, Jiao; Luo, Peihua; Zhu, Hong; Che, Jinxin; He, Qiaojun; Dong, Xiaowu. The article conveys some information:
Fibroblast growth factor receptor 4 (FGFR4) together with co-receptors modulate the activation of downstream proteins that regulate fundamental processes, and elevated FGFR4 activity is associated with Hepatocellular Carcinoma (HCC). Hence, FGFR4 is a promising therapeutic target for HCC. Based on BLU9931, authors designed and synthesized a series of phenylquinazoline derivatives as novel inhibitors of FGFR4 through the covalent reversible strategy. Among them, a novel compound I showed FGFR4 and cell proliferation inhibitory activity. Cellular mechanism studies demonstrated that compound I induced apoptosis via the FGFR4 signaling pathway blockage. Further mechanism study showed that I has the reversible covalent binding capacity, could be used as a reference for the development of novel FGFR4 covalent reversible inhibitors. The experimental part of the paper was very detailed, including the reaction process of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3HPLC of Formula: 51644-96-3)
Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).HPLC of Formula: 51644-96-3
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