On September 22, 1976, Miki, Tosaku; Ineoka, Mari; Isoda, Yoshiro; Okano, Junji published a patent.COA of Formula: C9H14O3 The title of the patent was Active amino acid. And the patent contained the following:
The methylcyclohexanecarboxylic acids I (R = 1-, 2-, or 3-Me), prepared in 5 steps from the oxo esters II (R1 = Me, Et) via treatment with HOCMe2CN, dehydration, hydrogenation, hydrolysis, and reduction, were isomerized on treating with p-MeC6H4SO3H (III) followed by a weakly basic ion exchange resin. Thus, treating a mixture of cis- and trans-I (R = 1-Me) with III in H2O 1 h at room temperature gave cis-I (R = Me).4-MeC6H4SO3H which was eluted through Amberlite IR-45 (OH form) to give cis-I (R = Me). The experimental process involved the reaction of Methyl 1-methyl-4-oxocyclohexanecarboxylate(cas: 37480-41-4).COA of Formula: C9H14O3
The Article related to methylcyclohexanecarboxylic acid isomerization, aminomethylcyclohexanecarboxylic acid, cyclohexanecarboxylic acid aminomethyl, Alicyclic Compounds: Cyclohexanes and other aspects.COA of Formula: C9H14O3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics