On July 31, 2020, Meng, Xin; Lian, Xujing; Li, Xiao; Ya, Qiang; Li, Tingshen; Zhang, Yongmin; Yang, Yang; Zhang, Yan published an article.HPLC of Formula: 2873-29-2 The title of the article was Synthesis of 2′-paclitaxel 2-deoxy-2-fluoro-glucopyranosyl carbonate for specific targeted delivery to cancer cells. And the article contained the following:
A novel 2-fluorodeoxyglucose conjugated derivative of paclitaxel was efficiently synthesized using a linker between 2′-OH of paclitaxel and C1-hydroxyl group of 2-fluorodeoxyglucose. In preparation of the prodrug, allyl carbonates were selected as the protective group and the efficient one-step removal of allyloxycarbonyl groups at the end of the synthesis using palladium chem. gave the target mol. in good yield. The prodrug not only improved the pharmaceutical properties of paclitaxel, such as solubility and stability, but also demonstrated enhanced cytotoxicity and selectivity for cancer cells and less toxicity toward normal HUVEC cells. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).HPLC of Formula: 2873-29-2
The Article related to paclitaxel deoxyfluoro glucopyranosyl carbonate preparation cancer prodrug delivery, chemotherapy, fluorodeoxyglucose, paclitaxel, prodrug, targeting drug delivery, Carbohydrates: Glycosides and other aspects.HPLC of Formula: 2873-29-2
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