On May 31, 2021, Kostopoulou, Ioanna; Diassakou, Antonia; Kavetsou, Eleni; Kritsi, Eftichia; Zoumpoulakis, Panagiotis; Pontiki, Eleni; Hadjipavlou-Litina, Dimitra; Detsi, Anastasia published an article.Quality Control of Methyl N-Methylanthranilate The title of the article was Novel quinolinone-pyrazoline hybrids: synthesis and evaluation of antioxidant and lipoxygenase inhibitory activity. And the article contained the following:
The present project deals with the investigation of structure-activity relationship of several quinolinone-chalcone and quinolinone-pyrazoline hybrids, in an effort to discover promising antioxidant and anti-inflammatory agents. In order to accomplish this goal, four bioactive hybrid quinolinone-chalcone compounds (8a-8d) were synthesized via an aldol condensation reaction, which were then chem. modified, forming fifteen new pyrazoline analogs (9a-9o). All the synthesized analogs were in vitro evaluated in terms of their antioxidant and soybean lipoxygenase (LOX) inhibitory activity. Among all the pyrazoline derivatives, compounds 9b and 9m were found to possess the best combined activity, whereas 9b analog exhibited the most potent LOX inhibitory activity, with IC50 value 10μM. The in silico docking results revealed that the synthetic pyrazoline analog 9b showed high AutoDock Vina score (- 10.3 kcal/mol), while all the tested derivatives presented allosteric interactions with the enzyme. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).Quality Control of Methyl N-Methylanthranilate
The Article related to pyrazoline quinolinone antioxidant lipoxygenase inhibitor lipid peroxidation, antioxidant activity, chalcones, lox inhibition, lipoxygenase, pyrazolines, quinolinones, Pharmacology: Structure-Activity and other aspects.Quality Control of Methyl N-Methylanthranilate
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