On November 30, 1979, Isoda, Sumiro; Hirata, Miyoshi published an article.Reference of Methyl 1-methyl-4-oxocyclohexanecarboxylate The title of the article was Medicinal chemical studies on antiplasmin drugs. III. 4-Aminomethylcyclohexanecarboxylic acid and its derivatives having a methyl group. And the article contained the following:
The 1-, 4-, and α-Me derivatives of cis- and trans-4-(aminomethyl)cyclohexanecarboxylic acid (I) were prepared None of the products showed a more potent antiplasmin activity (no data) than trans-I. NMR studies showed that the CH2NH3 group has a conformational free energy ΔG° = -1.4 kcal/mol. Biol. active trans-I has both ring substituents in the equatorial positions, whereas cis-I exists mainly in the axial CH2N+H3-equatorial CO2- form. The experimental process involved the reaction of Methyl 1-methyl-4-oxocyclohexanecarboxylate(cas: 37480-41-4).Reference of Methyl 1-methyl-4-oxocyclohexanecarboxylate
The Article related to aminomethylcyclohexanecarboxylic acid preparation antiplasmin, conformation aminomethylcyclohexanecarboxylic acid, cyclohexanecarboxylic acid aminomethyl, Alicyclic Compounds: Cyclohexanes and other aspects.Reference of Methyl 1-methyl-4-oxocyclohexanecarboxylate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics