Galanty, Agnieszka; Popiol, Justyna; Paczkowska-Walendowska, Magdalena; Studzinska-Sroka, Elzbieta; Pasko, Pawel; Cielecka-Piontek, Judyta; Pekala, Elzbieta; Podolak, Irma published an article in 2021, the title of the article was (+)-Usnic Acid as a Promising Candidate for a Safe and Stable Topical Photoprotective Agent.SDS of cas: 6197-30-4 And the article contains the following content:
The study aimed to examine whether usnic acid-a lichen compound with UV-absorbing properties-can be considered as a prospective photoprotective agent in cosmetic products. Moreover, a comparison of two usnic acid enantiomers was performed to preselect the more effective compound To meet this aim, an in vitro model was created, comprising the determination of skin-penetrating properties via skin-PAMPA assay, safety assessment to normal human skin cells (keratinocytes, melanocytes, fibroblasts), and examination of photostability and photoprotective properties. Both enantiomers revealed comparable good skin-penetrating properties. Left-handed usnic acid was slightly more toxic to keratinocytes (IC50 80.82 and 40.12 μg/mL, after 48 and 72 h, resp.) than its right-handed counterpart. The latter enantiomer, in a cosmetic formulation, was characterized by good photoprotective properties and photostability, comparable to the UV filter octocrylene. Perhaps most interestingly, (+)-usnic acid combined with octocrylene in one formulation revealed enhanced photoprotection and photostability. Thus, the strategy can be considered for the potential use of (+)-usnic acid as a UV filter in cosmetic products. Moreover, the proposed model may be useful for the evaluation of candidates for UV filters. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).SDS of cas: 6197-30-4
The Article related to acrylates: chemistry, benzofurans: chemistry, benzofurans: pharmacology, fibroblasts: drug effects, fibroblasts: radiation effects, humans, keratinocytes: drug effects, keratinocytes: radiation effects, melanocytes: drug effects, melanocytes: radiation effects, radiation-protective agents: chemistry, radiation-protective agents: pharmacology and other aspects.SDS of cas: 6197-30-4
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