On February 29, 2016, Eckert, Elisabeth; Muench, Frank; Goeen, Thomas; Purbojo, Ariawan; Mueller, Johannes; Cesnjevar, Robert published an article.Synthetic Route of 3319-31-1 The title of the article was Comparative study on the migration of di-2-ethylhexyl phthalate (DEHP) and tri-2-ethylhexyl trimellitate (TOTM) into blood from PVC tubing material of a heart-lung machine. And the article contained the following:
Medical devices like blood tubing often consist of PVC material that requires the addition of plasticizers. These plasticizers may migrate into the blood leading to an exposure of the patients. In this study the migration behavior of three different blood tubing sets (PVC material with two different plasticizers and silicone as control material) applied on a heart-lung machine standardly used for cardiopulmonary bypass (CPB) in children was studied. We analyzed the total plasticizer migration by anal. of both, the parent compounds as well as their primary degradation products in blood. Addnl., the total mass loss of the tubing over perfusion time was examined The PVC tubing plasticized with DEHP (di-2-ethylhexyl phthalate) was found to have the highest mass loss over time and showed a high plasticizer migration rate. In comparison, the migration of TOTM (tri-2-ethylhexyl trimellitate) and its primary degradation products was found to be distinctly lower (by a factor of approx. 350). Moreover, it was observed that the storage time of the tubing affects the plasticizer migration rates. In conclusion, the DEHP substitute TOTM promises to be an effective alternative plasticizer for PVC medical devices particularly regarding the decreased migration rate during medical procedures. The experimental process involved the reaction of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate(cas: 3319-31-1).Synthetic Route of 3319-31-1
The Article related to diethylhexyl phthalate triethylhexyl trimellitate pvc cardiopulmonary bypass blood tubing, blood tubing, leaching, medical devices, pvc, plasticizers, silicone, Pharmaceuticals: Biologicals and other aspects.Synthetic Route of 3319-31-1
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