On December 31, 2021, Akifuji, Chiaki; Iwasaki, Mio; Kawahara, Yuka; Sakurai, Chiho; Cheng, Yu-Shen; Imai, Takahiko; Nakagawa, Masato published an article.HPLC of Formula: 2358-84-1 The title of the article was MYCL promotes iPSC-like colony formation via MYC Box 0 and 2 domains. And the article contained the following:
Human induced pluripotent stem cells (hiPSCs) can differentiate into cells of the three germ layers and are promising cell sources for regenerative medicine therapies. However, current protocols generate hiPSCs with low efficiency, and the generated iPSCs have variable differentiation capacity among different clones. Our previous study reported that MYC proteins (c-MYC and MYCL) are essential for reprogramming and germline transmission but that MYCL can generate hiPSC colonies more efficiently than c-MYC. The mol. underpinnings for the different reprogramming efficiencies between c-MYC and MYCL, however, are unknown. In this study, we found that MYC Box 0 (MB0) and MB2, two functional domains conserved in the MYC protein family, contribute to the phenotypic differences and promote hiPSC generation in MYCL-induced reprogramming. Proteome analyses suggested that in MYCL-induced reprogramming, cell adhesion-related cytoskeletal proteins are regulated by the MB0 domain, while the MB2 domain regulates RNA processes. These findings provide a mol. explanation for why MYCL has higher reprogramming efficiency than c-MYC. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).HPLC of Formula: 2358-84-1
The Article related to mycl ipsc colony formation myc box domain, Mammalian Biochemistry: Blood and other aspects.HPLC of Formula: 2358-84-1
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