On October 1, 2021, Yang, Chao; Ma, Dejun; Lu, Liqing; Yang, Xing; Xi, Zhen published an article.SDS of cas: 882518-89-0 The title of the article was Synthesis of KUE-siRNA Conjugates for Prostate Cancer Cell-Targeted Gene Silencing. And the article contained the following:
The delivery of siRNAs to selectively target cells poses a great challenge in RNAi-based cancer therapy. The lack of suitable cell-targeting methods seriously restricts the advance in delivering siRNAs to extrahepatic tissues. Based on prostate-specific membrane antigen (PSMA)-targeting ligands, we have synthesized a series of lysine-urea-glutamate (KUE)-siRNA conjugates and verified their effective cell uptake and gene silencing properties in prostate cancers. The results indicated that the KUE-siRNA conjugates could selectively enter PSMA+ LNCaP cells, eventually down-regulating STAT3 expression. Based on post-synthesis modification and receptor-mediated endocytosis, this strategy of constructing ligand-siRNA conjugates might provide a general method of siRNA delivery for cell-targeted gene silencing. The experimental process involved the reaction of tert-Butyl 2-(2-(2-(tosyloxy)ethoxy)ethoxy)acetate(cas: 882518-89-0).SDS of cas: 882518-89-0
The Article related to lysine urea glutamate sirna prostate cancer cell gene silencing, kue-sirna conjugates, psma-targeted, rna interference, propargyl analog, prostate cancer, Placeholder for records without volume info and other aspects.SDS of cas: 882518-89-0
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