Su, Yajuan; Tian, Liang; Yu, Meng; Gao, Qiang; Wang, Dehui; Xi, Yuewei; Yang, Peng; Lei, Bo; Ma, Peter X.; Li, Peng published an article in 2017, the title of the article was Cationic peptidopolysaccharides synthesized by ′click′ chemistry with enhanced broad-spectrum antimicrobial activities.SDS of cas: 6038-19-3 And the article contains the following content:
The emergence and spread of multidrug-resistant (MDR) bacteria is a serious clin. problem, and a challenge for the medical research community. There is an urgent need to explore novel effective antimicrobial mols. Here, we report on a series of cationic peptidopolysaccharides that have a bacterial peptidoglycan-mimetic structure and have been synthesized using a facile thiol-ene ′click′ chem. to graft antimicrobial peptides, ε-poly-L-lysine (EPL), onto a polysaccharide (chitosan, CS) backbone. These CS-g-EPL copolymers demonstrated enhanced, selective, broad-spectrum antibacterial and antifungal activities towards Gram-neg. bacteria (Escherichia coli and Pseudomonas aeruginosa), Gram-pos. bacteria (Enterococcus faecalis and methicillin-resistant Staphylococcus aureus (MRSA)), and fungi (Candida albicans and Fusarium solani). Mechanistic studies proved that the CS-g-EPL likely disrupts the anionic microbial membrane leading to cell death, and is less likely to disrupt the mammalian cell membrane. In addition, CSL-g-EPL50% exhibits good in vitro biocompatibility with mammalian cells, and very little evidence of in vivo toxicity. Most importantly, CS-g-EPL demonstrated a strong antimicrobial efficacy with a log reduction of 4.66 in a rat MRSA infection model. These excellent biol. properties present a promising prospect for CS-g-EPL in biomedical applications. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).SDS of cas: 6038-19-3
The Article related to cationic peptidopolysaccharide click chem broad spectrum antimicrobial activity, Placeholder for records without volume info and other aspects.SDS of cas: 6038-19-3
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