On October 25, 2020, St-Gelais, Jacob; Cote, Emilie; Laine, Danny; Johnson, Paul A.; Giguere, Denis published an article.Product Details of 2873-29-2 The title of the article was Addressing the Structural Complexity of Fluorinated Glucose Analogues: Insight into Lipophilicities and Solvation Effects. And the article contained the following:
In this work, we synthesized all mono-, di-, and trifluorinated glucopyranose analogs at positions C-2, C-3, C-4, and C-6. This systematic investigation allowed us to perform direct comparison of 19F resonances of fluorinated glucose analogs and also to determine their lipophilicities. Compounds with a fluorine atom at C-6 are usually the most hydrophilic, whereas those with vicinal polyfluorinated motifs are the most lipophilic. Finally, the solvation energies of fluorinated glucose analogs were assessed for the first time by using d. functional theory. This method allowed the log P prediction of fluoroglucose analogs, which was comparable to the C log P values obtained from various web-based programs. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Product Details of 2873-29-2
The Article related to polyfluoro glucose preparation lipophilicity solvation effect, density functional theory, fluorine, glucopyranoses, lipophilicity, solvation energies, Carbohydrates: Monosaccharides, Glycals and other aspects.Product Details of 2873-29-2
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