On August 31, 2015, Qureshi, Zafar; Schlundt, Waldemar; Lautens, Mark published an article.Product Details of 3976-69-0 The title of the article was Introduction of Hindered Electrophiles via C-H Functionalization in a Palladium-Catalyzed Multicomponent Domino Reaction. And the article contained the following:
A general method for the incorporation of secondary alkyl iodides in a palladium-catalyzed multicomponent domino reaction is reported. With the relatively inexpensive Pd(OAc)2 as the catalyst and norbornene as a mediator, a variety of 1,2,3-trisubstituted aromatic compounds were synthesized. The reaction is scalable, producing excellent isolated yields on up to 5 mmol scale. Chiral alkyl iodides were also incorporated without any loss of stereochem. information. The developed method offers an expedient and mild C-H functionalization strategy for the synthesis of sterically congested aromatic compounds in a one-pot process. The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).Product Details of 3976-69-0
The Article related to trisubstituted aromatic compound preparation palladium catalyst multicomponent domino, General Organic Chemistry: Synthetic Methods and other aspects.Product Details of 3976-69-0
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