On April 10, 2020, Phan, Quoc Thang; Patil, Maheshkumar Prakash; Tu, Trang T. K.; Le, Cuong M. Q.; Kim, Gun-Do; Lim, Kwon Taek published an article.HPLC of Formula: 6038-19-3 The title of the article was Polyampholyte-grafted single walled carbon nanotubes prepared via a green process for anticancer drug delivery application. And the article contained the following:
We report a novel process for surface modified single-walled carbon nanotubes (SWCNTs) as drug nanocarriers by using facile and green synthetic methods. Firstly, polyampholytic alternating polymers having furfuryl amine and 3-(dimethylamino)-1-propylamine as functional groups were prepared via one-pot thiol-ene chem. in sustainable conditions. The obtained polymers were then used to a direct functionalization onto the surface of SWCNTs through Diels-Alder click reaction conducted in aqueous media under ultrasonication. The resulting hybrid was characterized by 1H NMR, FT-IR, TGA and UV-vis measurements. The hybrid improved the drug loading content up to 150 wt%, indicating that they are potential doxorubicin (DOX) delivery nano-vehicles. Furthermore, the in-vitro drug release profiles showed that there was a burst release of DOX at pH 5.5 under an acidic condition in microenvironment of tumor cells, in contrast with a lower release rate at pH 7.4 in the physiol. condition. Cell viability assays demonstrated the low cytotoxicity against the normal HEK293 cell of SWCNT hybrids, while they exhibited a high cytotoxic activity towards HeLa cancer cells. These evidences revealed the promising SWCNT-based drug carrier for tumor-targeting chemotherapy release in the cancer therapy. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).HPLC of Formula: 6038-19-3
The Article related to polyampholyte grafted carbon nanotube anticancer drug ph controlled release, Placeholder for records without volume info and other aspects.HPLC of Formula: 6038-19-3
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