Mori, Satoka; Abe, Arisa; Ishikawa, Naoto; Rafique, Abdur; Ito, Yuji published an article in 2021, the title of the article was A novel site-specific chemical conjugation of IgG antibodies by affinity peptide for immunoassays.HPLC of Formula: 79642-50-5 And the article contains the following content:
Recently, there has been an increasing interest in site-specific modifications of antibodies used in immunoassays for disease diagnosis and as antibody therapeutics, such as antibody-drug conjugates. Previously, we established a site-specific chem. conjugation system using an IgG-Fc binding chem. conjugation affinity peptide (CCAP). CCAP could be used only for the modification of human IgG owing to the lack of affinity of CCAP to rodent IgG mols. In this study, novel CCAP reagents are proposed, which can be used for both human and mouse IgG, based on the Staphylococcus aureus protein A domain-derived affinity peptides Z34C and Z33. Compared with the activity of a conventional randomly modified antibody, mouse IgG modified using this method had favorable features in two immunoassays, demonstrating the advantages of the proposed CCAP method in preserving antibody functionality during conjugation. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).HPLC of Formula: 79642-50-5
The Article related to staphylococcus aureus igg monoclonal antibodies peptide immunoassay, rpla, antibody, conjugation, immunoassay, peptide, protein a, Placeholder for records without volume info and other aspects.HPLC of Formula: 79642-50-5
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