On October 11, 2021, Mommer, Stefan; Gehlen, David; Akagi, Takami; Akashi, Mitsuru; Keul, Helmut; Moeller, Martin published an article.Electric Literature of 6038-19-3 The title of the article was Thiolactone-Functional Pullulan for In Situ Forming Biogels. And the article contained the following:
Gelation in the presence of cells with min. cytotoxicity is highly desirable for materials with applications in tissue engineering. Herein, the naturally occurring polysaccharide pullulan is functionalized with thiolactones that undergo ring-opening addition of amines. As a result, the modified pullulan can be crosslinked with diamines and/or amine-containing biol. substrates enhancing the system′s versatility (e.g., gelatin and cell-binding ligands GHK/GRGDS). Thiolactone degrees of substitution of 2.5 or 5.0 mol % are achieved, and resp. hydrogels exhibit mesh sizes of 27.8 to 49.1 nm. Cell proliferation studies on chosen gels (G′ ≃ 500 Pa, over 14 days) demonstrate that for normal human dermal fibroblasts (NHDFs), both gelatin and GRGDS equally support cell proliferation, while in the case of hepatocytes (HepG2), the presence of GRGDS and GHK improve cell proliferation 10-fold compared to gelatin. Cells remain viable and in one instance were successfully encapsulated by in situ gelation, altogether confirming the mild and biocompatible nature of this strategy to produce biogels using biol. active substrates as crosslinkers. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).Electric Literature of 6038-19-3
The Article related to thiolactone pullulan in situ biogel, Placeholder for records without volume info and other aspects.Electric Literature of 6038-19-3
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