On December 31, 2020, Mirzaei, Mehdi; Gupta, Vivek K.; Chitranshi, Nitin; Deng, Liting; Pushpitha, Kanishka; Abbasi, Mojdeh; Chick, Joel M.; Rajput, Rashi; Wu, Yunqi; McKay, Matthew J.; Salekdeh, Ghasem H.; Gupta, Veer B.; Haynes, Paul A.; Graham, Stuart L. published an article.Name: Oxybis(ethane-2,1-diyl) bis(2-methylacrylate) The title of the article was Retinal proteomics of experimental glaucoma model reveal intraocular pressure-induced mediators of neurodegenerative changes. And the article contained the following:
Current evidence suggests that exposure to chronically induced intraocular pressure (IOP) leads to neurodegenerative changes in the inner retina. This study aimed to determine retinal proteomic alterations in a rat model of glaucoma and compared findings with human retinal proteomics changes in glaucoma reported previously. We developed an exptl. glaucoma rat model by subjecting the rats to increased IOP (9.3 ± 0.1 vs 20.8 ± 1.6 mm Hg) by weekly microbead injections into the eye (8 wk). The retinal tissues were harvested from control and glaucomatous eyes and protein expression changes analyzed using a multiplexed quant. proteomics approach (TMT-MS3). Immunofluorescence was performed for selected protein markers for data validation. Our study identified 4304 proteins in the rat retinas. Out of these, 139 proteins were downregulated (≤0.83) while the expression of 109 proteins was upregulated (≥1.2-fold change) under glaucoma conditions (P ≤ .05). Computational anal. revealed reduced expression of proteins associated with glutathione metabolism, mitochondrial dysfunction/oxidative phosphorylation, cytoskeleton, and actin filament organization, along with increased expression of proteins in coagulation cascade, apoptosis, oxidative stress, and RNA processing. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Name: Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)
The Article related to glaucomatous retina glycoprotein oxidative stress glaucoma pathogenesis intraocular pressure, glaucoma, neurodegeneration, proteomics, retina, Placeholder for records without volume info and other aspects.Name: Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)
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