Li, Yan-An; Zhao, Xiao-Dong; Yin, Hai-Peng; Chen, Gong-Jun; Yang, Song; Dong, Yu-Bin published an article in 2016, the title of the article was A drug-loaded nanoscale metal-organic framework with a tumor targeting agent for highly effective hepatoma therapy.Computed Properties of 1312703-30-2 And the article contains the following content:
Drug delivery systems with targeting agents for precise drug release in cancer therapy are very significant and important. Herein, we report the rational design and synthesis of a DOX (doxorubicin) loaded UiO-68-type of nanoscale metal-organic framework (NMOF) with a tumor targeting agent (folic acid, FA), DOX@UiO-68-FA (3), as a multifunctional drug delivery system for hepatoma (Hep G2) therapy via tail-vein injection. Compared to free DOX, FA-unloaded DOX@Mi-UiO-68 (2), 3 exhibits a much higher antitumor efficacy, which was confirmed by cell imaging, standard 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) proliferation and in vivo experiments The experimental process involved the reaction of Dimethyl 2′-amino-[1,1′:4′,1”-terphenyl]-4,4”-dicarboxylate(cas: 1312703-30-2).Computed Properties of 1312703-30-2
The Article related to metal organic framework drug delivery system preparation hepatoma therapy, Pharmaceuticals: Formulation and Compounding and other aspects.Computed Properties of 1312703-30-2
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