On December 1, 2020, Kassotis, Christopher D.; Herkert, Nicholas J.; Hammel, Stephanie C.; Hoffman, Kate; Xia, Qianyi; Kullman, Seth W.; Sosa, Julie Ann; Stapleton, Heather M. published an article.Application In Synthesis of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate The title of the article was Thyroid Receptor Antagonism of Chemicals Extracted from Personal Silicone Wristbands within a Papillary Thyroid Cancer Pilot Study. And the article contained the following:
Research suggests that thyroid cancer incidence rates are increasing, and environmental exposures have been postulated to be playing a role. To explore this possibility, we conducted a pilot study to investigate the thyroid disrupting bioactivity of chem. mixtures isolated from personal silicone wristband samplers within a thyroid cancer cohort. Specifically, we evaluated TRβ antagonism of chem. mixtures extracted from wristbands (n = 72) worn by adults in central North Carolina participating in a case-control study on papillary thyroid cancer. Sections of wristbands were solvent-extracted and analyzed via mass spectrometry to quantify a suite of semivolatile chems. A second extract from each wristband was used in a bioassay to quantify TRβ antagonism in human embryonic kidney cells (HEK293/17) at concentrations ranging from 0.1 to 10% of the original extract (by volume). Approx. 70% of the sample extracts tested at a 1% extract concentration exhibited significant TRβ antagonism, with a mean of 30% and a range of 0-100%. Inhibited cell viability was noted in >20% of samples that were tested at 5 and 10% concentrations Antagonism was pos. associated with wristband concentrations of several phthalates, organophosphate esters, and brominated flame retardants. These results suggest that personal passive samplers may be useful in evaluating the bioactivities of mixtures that people contact on a daily basis. We also report tentative associations between thyroid receptor antagonism, chem. concentrations, and papillary thyroid cancer case status. Future research utilizing larger sample sizes, prospective data collection, and measurement of serum thyroid hormone levels (which were not possible in this study) should be utilized to more comprehensively evaluate these associations The experimental process involved the reaction of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate(cas: 3319-31-1).Application In Synthesis of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate
The Article related to thyroid receptor antagonist silicone wristband papillary thyroid cancer, Placeholder for records without volume info and other aspects.Application In Synthesis of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics