On September 6, 2013, Hama, Takuo; Ge, Shaozhong; Hartwig, John F. published an article.Name: tert-Butyl 2-(4-nitrophenyl)acetate The title of the article was Palladium-Catalyzed α-Arylation of Zinc Enolates of Esters: Reaction Conditions and Substrate Scope. And the article contained the following:
The intermol. α-arylation of esters by palladium-catalyzed coupling of aryl bromides with zinc enolates of esters is reported. Reactions of three different types of zinc enolates have been developed. α-Arylation of esters occurs in high yields with isolated Reformatsky reagents, with Reformatsky reagents generated from α-bromo esters and activated zinc, and with zinc enolates generated by quenching alkali metal enolates of esters with zinc chloride. The use of zinc enolates, instead of alkali metal enolates, greatly expands the scope of the arylation of esters. The reactions occur at room temperature or at 70° with bromoarenes containing cyano, nitro, ester, keto, fluoro, enolizable hydrogen, hydroxyl, or amino functionality and with bromopyridines. The scope of esters encompasses acyclic acetates, propionates, and isobutyrates, α-alkoxyesters, and lactones. The arylation of zinc enolates of esters was conducted with catalysts bearing the hindered pentaphenylferrocenyl di-tert-butylphosphine (Q-phos) or the highly reactive dimeric Pd(I) complex {[P(t-Bu)3]PdBr}2. The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).Name: tert-Butyl 2-(4-nitrophenyl)acetate
The Article related to palladium catalysis alpha arylation ester aryl bromide zinc enolate, General Organic Chemistry: Synthetic Methods and other aspects.Name: tert-Butyl 2-(4-nitrophenyl)acetate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics