On December 31, 2021, Guo, Yu; Wang, Ruo-Ya; Kang, Jia-Xin; Ma, Yan-Na; Xu, Cong-Qiao; Li, Jun; Chen, Xuenian published an article.Quality Control of Methyl N-Methylanthranilate The title of the article was Efficient synthesis of primary and secondary amides via reacting esters with alkali metal amidoboranes. And the article contained the following:
Authors report here a facile synthesis method of primary and secondary amides through a direct amidation of esters with sodium amidoboranes (NaNHRBH3, R = H, Me), at room temperature without using catalysts and other reagents. This process is rapid and chemoselective, and features quant. conversion and wide applicability for esters tolerating different functional groups. The exptl. and theor. studies reveal a reaction mechanism with nucleophilic addition followed by a swift proton transfer-induced elimination reaction. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).Quality Control of Methyl N-Methylanthranilate
The Article related to primary secondary amide preparation chemoselective, ester sodium amidoborane amidation, General Organic Chemistry: Synthetic Methods and other aspects.Quality Control of Methyl N-Methylanthranilate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics