On June 13, 2016, Gao, Jingyi; Wang, Mingzhi; Wang, Fangyingkai; Du, Jianzhong published an article.Formula: C4H8ClNOS The title of the article was Synthesis and Mechanism Insight of a Peptide-Grafted Hyperbranched Polymer Nanosheet with Weak Positive Charges but Excellent Intrinsically Antibacterial Efficacy. And the article contained the following:
Antimicrobial resistance is an increasingly problematic issue in the world and there is a present and urgent need to develop new antimicrobial therapies without drug resistance. Antibacterial polymers are less susceptible to drug resistance but they are prone to inducing serious side effects due to high pos. charge. Herein we report a peptide-grafted hyperbranched polymer which can self-assemble into unusual nanosheets with highly effective intrinsically antibacterial activity but weak pos. charges (+ 6.1 mV). The hyperbranched polymer was synthesized by sequential Michael addition-based thiol-ene and free radical mediated thiol-ene reactions, and followed by ring-opening polymerization of N-carboxyanhydrides (NCAs). The nanosheet structure was confirmed by transmission electron microscopy (TEM) and at. force microscopy (AFM) studies. Furthermore, a novel “wrapping and penetrating” antibacterial mechanism of the nanosheets was revealed by TEM and it is the key to significantly decrease the pos. charges but have a very low min. inhibitory concentration (MIC) of 16 μg mL-1 against typical Gram-pos. and Gram-neg. bacteria. Overall, our synthetic strategy demonstrates a new insight for synthesizing antibacterial nanomaterials with weak pos. charges. Moreover, the unique antibacterial mechanism of our nanosheets may be extended for designing next-generation antibacterial agents without drug resistance. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).Formula: C4H8ClNOS
The Article related to peptide graft hyperbranched polymer nanosheet antibacterial, Pharmaceuticals: Formulation and Compounding and other aspects.Formula: C4H8ClNOS
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics