Ganguly, Kumkum; Wu, Ruilian; Ollivault-Shiflett, Morgane; Goodwin, Peter M.; Silks, Louis A. III; Iyer, Rashi published an article in 2011, the title of the article was Design, synthesis, and a novel application of quorum-sensing agonists as potential drug-delivery vehicles.Application In Synthesis of 3-Aminodihydrothiophen-2(3H)-one hydrochloride And the article contains the following content:
Surface adhered bacterial colonies or biofilms are an important problem in medical and food industries. Bacteria use a chem. language to monitor their quorum and to express virulence factors, which eventually help them in colonization and manifestation of an infection. The LasR-LasI and RhlR-RhlI quorum-sensing (QS) systems of Pseudomonas aeruginosa control expression of virulence factors in a population d.-dependent fashion. In this study, we investigated the role of synthetic analogs to RhIR-RhII system of P. aeruginosa strains (PAO-1; wild-type and mutants JP-1, PDO-100, and JP-2) responsible for production of acyl-homoserine lactones-2; butanol homoserine lactone (AHL-2; C4-HSL). We synthesized double (QS1207) and single (QS0108) sulfur analogs against (C4-HSL; AHL-2), an autoinducer of Pseudomonas QS system. Extensive biol. investigation of these analogs suggested a growth promoting activity for these analogs in Pseudomonas controlling biofilm production and exo-protease secretion. We hypothesized that these thiolactone analogs could be potentially utilized as potent drug-delivery vehicles against biofilm-producing pathogens. As a proof of principle we conjugated the single sulfur analog QS0108 with the broad-spectrum antibiotic, ciprofloxacin (QS0108-Cip). The QS analog-antibiotic conjugate was significantly more effective at disrupting both the nascent and mature biofilms of P. aeruginosa than the free antibiotic. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).Application In Synthesis of 3-Aminodihydrothiophen-2(3H)-one hydrochloride
The Article related to antibiotic conjugate thiobutyrylhomocysteine thiolactone quorum sensing agonist preparation, Pharmaceuticals: Formulation and Compounding and other aspects.Application In Synthesis of 3-Aminodihydrothiophen-2(3H)-one hydrochloride
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics