On August 14, 2020, Feng, Shaojie; Xiong, Chenghe; Wang, Guirong; Wang, Subo; Jin, Guoxia; Gu, Guofeng published an article.Name: Bis(2,5-dioxopyrrolidin-1-yl) glutarate The title of the article was Exploration of Recombinant Fusion Proteins YAPO and YAPL as Carrier Proteins for Glycoconjugate Vaccine Design against Streptococcus pneumoniae Infection. And the article contained the following:
Pneumolysin (Ply), pneumococcal surface protein A (PspA), and pneumococcal surface adhesin A (PsaA) are promising cell surface protein antigen targets for Streptococcus pneumoniae (Spn) vaccine development. We designed and recombined 2 fusion proteins, named YAPO and YAPL, which contained the main antigenic epitopes of Ply, PspA, and PsaA. In-depth immunol. evaluations revealed that YAPO and YAPL had strong immunocompetence to be well-qualified potential carrier proteins. To verify this possibility, a serotype 3 Spn (ST3) capsular polysaccharide pentasaccharide was conjugated to each fusion protein to generate the resultant glycoconjugates. Immunol. studies in mice revealed that, as compared with TT conjugate, YAPO and YAPL conjugates provoked robust T-cell-dependent immune responses that could provide better recognition, in vitro efficient opsonophagocytosis, and in vivo effective protection against various serotypes of Spn. Collectively, YAPO and YAPL were identified as immunopotentiating carriers that could help convert immunol. inactive ST3 pentasaccharide into a T cell-dependent antigen and provide efficient and broad spectrum of immunoprotection coverage so as to formulate functional glycoconjugate vaccines against Spn infections. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).Name: Bis(2,5-dioxopyrrolidin-1-yl) glutarate
The Article related to streptococcus glycoconjugate vaccine yapo yapl carrier protein, streptococcus pneumoniae, carrier protein, fusion protein, glycoconjugate vaccine, immunoprotection, Placeholder for records without volume info and other aspects.Name: Bis(2,5-dioxopyrrolidin-1-yl) glutarate
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