Espeel, Pieter; Carrette, Lieselot L. G.; Bury, Katarzyna; Capenberghs, Sven; Martins, Jose C.; Du Prez, Filip E.; Madder, Annemieke published an article in 2013, the title of the article was Multifunctionalized Sequence-Defined Oligomers from a Single Building Block.Safety of 3-Aminodihydrothiophen-2(3H)-one hydrochloride And the article contains the following content:
A thiolactone-based approach for the solid-supported preparation of multifunctionalized sequence-defined oligomers was successfully developed. The elaborated two-step iterative method, consisting of an on-resin aminolysis and subsequent chain extension through Michael addition, does not require protecting groups and relies on the use of a single, readily available thiolactone acrylamide building block. Several functionalized short (up to tetrameric) sequences were obtained by consecutive use of a variety of com. available amines. The obtained sequence-defined motifs featuring a unique backbone and a preprogrammed organization of functionalized side chains were fully characterized by NMR spectroscopy and HRMS. These species could potentially exhibit tunable folding and self-association properties, predominantly determined by the nature of the functionalized amines. In this regard, high-throughput automation and control over the stereochem., induced by the use of enantiomerically pure building blocks, will be further explored. Moreover, through further application of thiolactones as latent thiol functionalities and installation of appropriate functional end groups, these short heterotelechelic fragments are susceptible to periodic polymerization, a process expected to afford larger sequence-controlled polymers. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).Safety of 3-Aminodihydrothiophen-2(3H)-one hydrochloride
The Article related to thiolactone oligomer solid phase synthesis self association, chemoselectivity, sequence-defined oligomers, solid-phase synthesis, synthetic methods, thiolactone, Chemistry of Synthetic High Polymers: Other and other aspects.Safety of 3-Aminodihydrothiophen-2(3H)-one hydrochloride
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