On August 10, 2020, Ding, Zexuan; Liu, Guhuan; Hu, Jinming published an article.Quality Control of 3-Aminodihydrothiophen-2(3H)-one hydrochloride The title of the article was Ratiometric Fluorescent Mapping of pH and Glutathione Dictates Intracellular Transport Pathways of Micellar Nanoparticles. And the article contained the following:
Visualization of intracellular transport pathways is crucial to investigate the internalization mechanism and understand the intracellular behavior of nanomaterials. Herein, we rationalized the design of micellar nanoparticles (NPs) for ratiometric fluorescent mapping of intracellular pH and glutathione (GSH), two essential parameters for maintaining normal cellular functions. Specifically, pH-sensitive naphthalimide-based probe (NPI) and pH-inert rhodamine B (RhB) were covalently labeled to double hydrophilic block copolymers (DHBCs) using the thiolactone chem., enabling the covalent attachment of NPI and RhB to one mol. with a redox-responsive disulfide linkage. The dually labeled DHBCs exhibited blue/orange dual emissions in acidic pH, which was further converted into green/orange dual emissions in neutral pH because of the deprotonation of NPI moieties and the sole green emission in the presence of GSH at neutral pH because of the decreased Forster resonance energy transfer efficiency between an NPI donor and an RhB acceptor as a result of GSH-mediated cleavage of disulfide bonds. These remarkable ratiometric fluorescence changes allowed for not only the simultaneous mapping of the intracellular pH and GSH but also the intracellular transport pathways of internalized NPs. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).Quality Control of 3-Aminodihydrothiophen-2(3H)-one hydrochloride
The Article related to ratiometry fluorescence mapping ph glutathione cell internalization micelle nanoparticle, Pharmaceuticals: Formulation and Compounding and other aspects.Quality Control of 3-Aminodihydrothiophen-2(3H)-one hydrochloride
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics