On December 31, 2020, Cook, David P.; Vanderhyden, Barbara C. published an article.HPLC of Formula: 2358-84-1 The title of the article was Context specificity of the EMT transcriptional response. And the article contained the following:
Epithelial-mesenchymal plasticity contributes to many biol. processes, including tumor progression. Various epithelial-mesenchymal transition (EMT) responses have been reported and no common, EMT-defining gene expression program has been identified. Here, we have performed a comparative anal. of the EMT response, leveraging highly multiplexed single-cell RNA sequencing (scRNA-seq) to measure expression profiles of 103,999 cells from 960 samples, comprising 12 EMT time course experiments and independent kinase inhibitor screens for each. We demonstrate that the EMT is vastly context specific, with an average of only 22% of response genes being shared between any two conditions, and over half of all response genes were restricted to 1-2 time course experiments Further, kinase inhibitor screens revealed signaling dependencies and modularity of these responses. These findings suggest that the EMT is not simply a single, linear process, but is highly variable and modular, warranting quant. frameworks for understanding nuances of the transition. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).HPLC of Formula: 2358-84-1
The Article related to lung prostate cancer progression tgm2 tgfb1 cdh1 emt, Placeholder for records without volume info and other aspects.HPLC of Formula: 2358-84-1
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