Churusova, Svetlana G. et al. published their research in Inorganic Chemistry in 2021 |CAS: 6038-19-3

The Article related to palladium pincer complex cysteine homocysteine residue antitumor agent cytotoxicity, Placeholder for records without volume info and other aspects.Recommanded Product: 6038-19-3

On July 5, 2021, Churusova, Svetlana G.; Aleksanyan, Diana V.; Rybalkina, Ekaterina Yu.; Susova, Olga Yu.; Peregudov, Alexander S.; Brunova, Valentina V.; Gutsul, Evgenii I.; Klemenkova, Zinaida S.; Nelyubina, Yulia V.; Glushko, Valentina N.; Kozlov, Vladimir A. published an article.Recommanded Product: 6038-19-3 The title of the article was Palladium(II) Pincer Complexes of Functionalized Amides with S-Modified Cysteine and Homocysteine Residues: Cytotoxic Activity and Different Aspects of Their Biological Effect on Living Cells. And the article contained the following:

In the search for potential new metal-based antitumor agents, two series of nonclassical palladium(II) pincer complexes based on functionalized amides with S-modified cysteine and homocysteine residues have been prepared and fully characterized by 1D and 2D NMR (1H, 13C, COSY, HMQC or HSQC, 1H-13C, and 1H-15N HMBC) and IR spectroscopy and, in some cases, X-ray diffraction. Most of the resulting complexes exhibit a high level of cytotoxic activity against several human cancer cell lines, including colon (HCT116), breast (MCF7), and prostate (PC3) cancers. Some of the compounds under consideration are also efficient in both native and doxorubicin-resistant transformed breast cells HBL100, suggesting the prospects for the creation of therapeutic agents based on the related compounds that would be able to overcome drug resistance. An anal. of different aspects of their biol. effects on living cells has revealed a remarkable ability of the S-modified derivatives to induce cell apoptosis and efficient cellular uptake of their fluorescein-conjugated counterpart, confirming the high anticancer potential of Pd(II) pincer complexes derived from functionalized amides with S-donor amino acid pendant arms. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).Recommanded Product: 6038-19-3

The Article related to palladium pincer complex cysteine homocysteine residue antitumor agent cytotoxicity, Placeholder for records without volume info and other aspects.Recommanded Product: 6038-19-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics