On January 31, 2016, Chen, Xian-Hua; Ma, Li; Hu, Yi-Xiang; Wang, Dan-Xian; Fang, Li; Li, Xue-Lai; Zhao, Jin-Chuan; Yu, Hai-Rong; Ying, Hua-Zhong; Yu, Chen-Huan published an article.HPLC of Formula: 3319-31-1 The title of the article was Transcriptome profiling and pathway analysis of hepatotoxicity induced by tris (2-ethylhexyl) trimellitate (TOTM) in mice. And the article contained the following:
Tris (2-ethylhexyl) trimellitate (TOTM) is commonly used as an alternative plasticizer for medical devices. But very little information was available on its biol. effects. In this study, the authors investigated toxicity effects of TOTM on hepatic differential gene expression analyzed by using high-throughput sequencing anal. for over-represented functions and phenotypically anchored to complementary histopathol., and biochem. data in the liver of mice. Among 1668 candidate genes, 694 genes were up-regulated and 974 genes were down-regulated after TOTM exposure. Using Gene Ontol. anal., TOTM affected three processes: the cell cycle, metabolic process and oxidative activity. Furthermore, 11 key genes involved in the above processes were validated by real time PCR. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway anal. revealed that these genes were involved in the cell cycle pathway, lipid metabolism and oxidative process. It revealed the transcriptome gene expression response to TOTM exposure in mouse, and these data could contribute to provide a clearer understanding of the mol. mechanisms of TOTM-induced hepatotoxicity in human. The experimental process involved the reaction of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate(cas: 3319-31-1).HPLC of Formula: 3319-31-1
The Article related to tris ethylhexyl trimellitate hepatotoxicity transcriptome, cell cycle, cytochrome p450, digital gene expression profiling, lipid metabolism, oxidative process, Toxicology: Methods (Including Analysis) and other aspects.HPLC of Formula: 3319-31-1
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics