On September 30, 2020, Azambuja, J. H.; Schuh, R. S.; Michels, L. R.; Iser, I. C.; Beckenkamp, L. R.; Roliano, G. G.; Lenz, G. S.; Scholl, J. N.; Sevigny, J.; Wink, M. R.; Stefani, M. A.; Battastini, A. M. O.; Figueiro, F.; Teixeira, H. F.; Braganhol, E. published an article.HPLC of Formula: 2358-84-1 The title of the article was Blockade of CD73 delays glioblastoma growth by modulating the immune environment. And the article contained the following:
Abstract: Immunotherapy as an approach for cancer treatment is clin. promising. CD73, which is the enzyme that produces extracellular adenosine, favors cancer progression and protects the tumor from immune surveillance. While CD73 has recently been demonstrated to be a potential target for glioma treatment, its role in regulating the inflammatory tumor microenvironment has not yet been investigated. Thus, this study explores the immunotherapeutic value of the CD73 blockade in glioblastoma. The immuno-therapeutic value of the CD73 blockade was evaluated in vivo in immunocompetent pre-clin. glioblastoma model. As such, glioblastoma-bearing rats were nasally treated for 15 days with a siRNA CD73-loaded cationic-nanoemulsion (NE-siRNA CD73R). Apoptosis was determined by flow cytometry using Annexin-V staining and cell proliferation was analyzed by Ki67 expression by immunohistochem. The treatment selectively decreased CD73 expression in the GB cells as well as in the tumor-associated-macrophages/microglia. This study indicates that CD73 knockdown using a nanotechnol. approach to perform nasal delivery of siRNA-CD73 to CNS can potentially regulate the glioblastoma immune microenvironment and delay tumor growth by inducing apoptosis. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).HPLC of Formula: 2358-84-1
The Article related to cd73 glioblastoma growth immune environment, ecto-5′-nucleotidase/cd73, glioblastoma, immunotherapy, macrophages, microglia, t regulatory lymphocytes, Placeholder for records without volume info and other aspects.HPLC of Formula: 2358-84-1
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