Zhao, Qichao; Twu, Pamela; Anderson, Jared L. published an article in 2012, the title of the article was A rapid analytical method for monitoring the enantiomeric purity of chiral molecules synthesized in ionic liquid solvents.Category: esters-buliding-blocks And the article contains the following content:
Ionic liquids (ILs) were widely used as reaction solvents in asym. synthesis due to their interesting phys. and chem. properties. However, monitoring reactant-to-product conversion and the enantiopurity of formed stereoisomers often involves a tedious extraction step before chromatog. anal. A rapid and sensitive sampling method using headspace solid-phase microextraction (SPME) coupled to chiral gas chromatog. was developed for the online anal. of chiral mols. in the IL solvent. Three different SPME sorbent coatings, polydimethylsiloxane, polyacrylate, and a polymeric ionic liquid-based fiber, were examined The anal. performance of the developed method was evaluated in terms of reproducibility, slope of calibration curve, linear range, calibration linearity, and the determination of detection limits. The SPME method was successfully applied in the determination of enantiomeric excess from selected mixtures of chiral mols. A preliminary study was performed using an on-fiber derivatization approach revealing that the stereoisomers extracted by the SPME fiber can be efficiently derivatized using a short on-fiber derivatization step. The developed SPME method eliminates the need of sequestering the reaction, separating the compounds of interest from the IL solvent, and the addition of a derivatizing reagent. Chirality, 2012. © 2012 Wiley Periodicals, Inc. The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).Category: esters-buliding-blocks
The Article related to enantiomeric purity monitoring chiral mol synthesis ionic liquid solvent, headspace solid phase microextraction gc enantiomeric purity monitoring, Organic Analytical Chemistry: Determinations and other aspects.Category: esters-buliding-blocks
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics