On May 1, 2020, Ye, Jianlong; Chu, Jiachen; Yin, Jian; Zhang, Yufeng; Meng, Jianqiang published an article.SDS of cas: 6038-19-3 The title of the article was Surface modification of regenerated cellulose membrane based on thiolactone chemistry – A novel platform for mixed mode membrane adsorbers. And the article contained the following:
Mixed-mode membrane chromatog. (MMC) is an efficient separation technol. for protein purification However, tedious preparation methods and difficulty on ligand d. control for its stationary phase limit the application of MMC. Herein we explored a one-pot multistep reaction based on the thiolactone chem. as a platform for membrane surface modification design toward mixed mode membrane adsorbers. The regenerated cellulose (RC) membrane was modified by the atom transfer radical polymerization (ATRP) of styrene-thiolactone (St-Tla), followed by the amine-thiol-ene conjugation. N-butylamine/methacrylic acid and octylamine/methacrylic acid were selected as the modifier to prepare two different mixed mode membrane adsorbers, RC-HIC/IEC (hydrophobic/ion-exchange) and RC-RPC/IEC (reversed phase/ion-exchange). SEM, FT-IR and XPS results showed that the membrane adsorbers were successfully prepared The RC-HIC/IEC membrane had a statistic adsorption capacity of 73.5μg/cm2 for human IgG (IgG) under the conditions of pH = 8 and 0.5 mol/L NaCl in PB buffer. The RC-RPC/IEC membrane showed a capacity of 70μg/cm2 for α-chymotrypsin (α-CTP) under the conditions of pH = 6.5 in PB buffer. The feasibility of tethering multi functions onto membrane surface via the thiolactone chem. was demonstrated in this work. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).SDS of cas: 6038-19-3
The Article related to surface modification cellulose membrane thiolactone adsorption adsorbent, Surface Chemistry and Colloids: Solid-Liquid Systems and other aspects.SDS of cas: 6038-19-3
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