On December 26, 2019, Yang, Xiaobao; Jiang, Biao; Sun, Ning; Qiu, Xing published a patent.Recommanded Product: tert-Butyl 2-(2-(2-(tosyloxy)ethoxy)ethoxy)acetate The title of the patent was Method for preparation of lenalidomide derivatives. And the patent contained the following:
Provided is a method for preparing a compound of formula I [wherein X = O, CONH, NHCO, NH, alkynylene, alkylidene, cycloalkylene, arylene, heterocylidene, or heteroarylene; Y = optionally protected COOH, -SO3H, NH2, N3, alkenyl, alkynyl, cyclofluorenyl, aryl, heterocyclyl, heteroaryl or hydrogen]. The preparation method comprises: a lenalidomide derivative undergoes an aminoalkylation reaction with a compound of formula R-X-Y [wherein R = a leaving group] in the presence of an organic alkali. For example, nalidamine, n-propylbromide, and N,N-diisopropylethylamine were added to a reaction tube, and then NMP was added, and the reaction was carried out at 110 °C for 6 h to give 1-oxo-4-propylamino-2-(2,6-dioxopiperidin-3-yl)isoindole as a final product. The experimental process involved the reaction of tert-Butyl 2-(2-(2-(tosyloxy)ethoxy)ethoxy)acetate(cas: 882518-89-0).Recommanded Product: tert-Butyl 2-(2-(2-(tosyloxy)ethoxy)ethoxy)acetate
The Article related to preparation lenalidomide derivative, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Recommanded Product: tert-Butyl 2-(2-(2-(tosyloxy)ethoxy)ethoxy)acetate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics