On September 28, 2006, Xu, Le-Cun; Vlahov, Iontcho Radoslavov; Leamon, Christopher Paul; Santhapuram, Hari Krishna; Li, Chunhong published a patent.SDS of cas: 53838-27-0 The title of the patent was Synthesis and purification of pteroic acid and conjugates thereof. And the patent contained the following:
Methods for purifying pteroic acid, analogs of pteroic acid, and derivatives of pteroic acid are described. Methods for synthesizing and purifying conjugates of vitamins, including FITC conjugates of folic acid, folic acid analogs, and derivatives of folic acid and folic acid analogs are also described. Purified forms of pteroic acid, derivatives and analogs of pteroic acid, and conjugates thereof were also described. Thus, folate-fluorescein conjugate I via a synthetic sequence starting from FITC N10-trifluoroacetyl-protected pteroic acid, glutamate α-tert-butyl-γ-Me diester and ethylene diamine. I was tested for its effect on the growth of solid tumors. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).SDS of cas: 53838-27-0
The Article related to pteroic acid conjugate preparation immunostimulant, antitumor activity folate fluorescein conjugate preparation, Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.SDS of cas: 53838-27-0
Referemce:
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