On August 6, 2021, Wen, Shijun; Huang, Peng; Tu, Yalin; Sun, Yameng; Hu, Yumin published a patent.Related Products of 882518-89-0 The title of the patent was Preparation of small molecule compounds based on degradation of EZH2 protein and their applications. And the patent contained the following:
The present invention relates to the preparation of small mol. compounds based on degradation of EZH2 protein and their applications. In particular, the small mol. compound I (wherein, X = a linker including acyclic or cyclic saturated or unsaturated carbon, ethylene glycol, amide, amino, ether, or carbonyl-containing group; Y = can be a group of affinity E3 ligase VHL or Cereblon (CRBN)) was prepared The inventive EZH2 degrading agents that can specifically degrade EZH2 protein, and these small mol. compounds has a stronger anti-tumor effect compared with EZH2 inhibitors. The experimental process involved the reaction of tert-Butyl 2-(2-(2-(tosyloxy)ethoxy)ethoxy)acetate(cas: 882518-89-0).Related Products of 882518-89-0
The Article related to heterocyclic small mol compound preparation ezh2 protein antitumor agent, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Related Products of 882518-89-0
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics