Weber, Sandra; Schmidt, Tamina; Schumacher, Paul; Kuballa, Thomas; Mildau, Gerd; Walch, Stephan G.; Hartwig, Andrea; Lachenmeier, Dirk W. published an article in 2019, the title of the article was Quantification of mineral oil aromatic hydrocarbons (MOAH) in anhydrous cosmetics using 1H NMR.Synthetic Route of 118-55-8 And the article contains the following content:
In cosmetic products, hydrocarbons from mineral oil origin are used as ingredients in a wide variety of consistency, from liquid oil to solid wax. Refined mineral oil hydrocarbons consist of MOSH and a low proportion of MOAH (mineral oil aromatic hydrocarbons). In the context of precautionary consumer protection, it is crucial to determine hydrocarbons from mineral oil origin of inferior quality quickly and efficiently. This publication presents a rapid method for quantifying MOAH by proton NMR spectroscopy (1H qNMR) in anhydrous cosmetics such as lipstick, lip gloss, and lip balm. A sample clean-up using solid-phase extraction was developed for the complete removal of interfering aromatic substances to improve the robustness of the method for analyzing compounded cosmetics. In preliminary trials using silica gel thin-layer chromatog., the retention behavior of 21 common aromatic compounds was tested in eluents with different solvent strength including EtOAc, MeOH, cyclohexane, and dichloromethane. Based on these results, the SPE sample cleanup with silica gel and cyclohexane as an eluent was suggested as best suitable for the purpose. The SPE cleanup was successfully achieved for all tested potentially interfering aromatic cosmetic ingredients except for butylated hydroxytoluene. The recovery for lipophilic cosmetics is more than 80% based on naphthalene as calculation equivalent The 1H qNMR method is a good complement to the LC-GC-FID method, which is predominantly used for the determination of MOSH and MOAH. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Synthetic Route of 118-55-8
The Article related to anhydrous cosmetics mineral oil aromatic hydrocarbon nmr spectroscopy, Essential Oils and Cosmetics: Skin Preparations and other aspects.Synthetic Route of 118-55-8
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