On December 5, 1995, Oshida, Junichi; Kawabata, Hiroshi; Kato, Yoshinori; Kokubo, Masayuki; Ueshima, Yasuhide; Sato, Osami; Fujii, Katsuhiko published a patent.Product Details of 53838-27-0 The title of the patent was Preparation of amino acid moiety-containing benzoxazines as elastase inhibitors. And the patent contained the following:
The title compounds I [R1 = H, alkyl; X = Y1A1, Y2(A2)mA3; when X is Y1A1 : R2, R3 = H, (carboxy)alkyl, or NR2R3 = ring; when X is Y2(A2)mA3 : R2 = alkyl, R3 = H; Y1 = amino-protecting group; Y2 = H, sulfonyl; A1, A2 = amino acid residue, etc.; A3 = lysine residue, etc.; m = 0 or 1] are prepared 7-(N-benzyloxycarbonyl-L-phenylalanyl)amino-5-methyl-2-(1-carboxyethyl)amino-4H-3,1-benzoxazin-4-one (preparation given) in vitro showed IC50 values of 5.1 x 10-8 M and 1.5 x 10-6 M against elastase and chymotrypsin, resp. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Product Details of 53838-27-0
The Article related to amino acid benzoxazine preparation elastase inhibitor, elastase inhibitor amino acid benzoxazine preparation, Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.Product Details of 53838-27-0
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